The large surface area and high pore volume of the NLAB Saga™ combined with controlled particle size and particle distribution result in a silica with high loading capacity, high chemical stability and low backpressure, well suited for preparative use and that is easy to pack.
In large scale purification of proteins and peptides there will be depositions in the packing material. To avoid time consuming packing and unpacking of the columns it is important to run cleaning in process, usually performed at a very high pH. Such conditions are harsh for the silica, hence it is of great importance that the silica survive under these conditions in order to have a long lasting product. Comparison of NLAB Saga™ to competitors in terms of alkaline stability shows that NLAB Saga™ withstands the harsh experimental conditions and performs consistently well – comparable with the market leader and well ahead of other competitors.
The NLAB Saga™ silica for preparative chromatography is produced at the contract manufacturer Sterling Pharma Solutions in the UK, using Nanologica’s technology, in order to provide the large volumes of silica required for preparative chromatography.