NLAB Spiro™

NLAB Spiro™

Nanologica develops nanoporous silica particles as a free-flowing powder tailored for pulmonary drug delivery. The spherical particles are produced in the size range of 2 µm to 5 µm, with narrow particle size distribution, to best reach the desired target site in the lung. The particles are non-aggregating, carry a high drug load, offer a controlled and sustained release profile and are soluble in simulated lung fluid.

Nanologica’s  patented NLAB Spiro™ technology solves problems in pharmaceutical formulations by improving  solubility, enhancing bioavailability and protecting APIs from degradation.

Increased release of API in simulated lung fluid

Picture: When the API is loaded into NLAB Spiro™ particles the bioavailability increased dramatically compared to the commercial formulation of the API. 

The aerodynamic properties of the particles are perfectly tailored for inhalation. Below show the MMADs (mass median aerodynamic diameter) for the NLAB Spiro™ particles loaded with three different APIs.

If you would like to know more about Nanologica’s drug delivery technology, please contact Prof. Adam Feiler, CTO adam.feiler@nanologica.com.

For more information:

NLAB Silica – Nanologica’s Technology Platform for Drug Delivery

NLAB Spiro™ – Pulmonary Delivery

Benefit of NLAB Spiro™

• Enhancing dissolution kinetics of poorly soluble compounds
• Controlling release kinetics
• Improving bioavailability
• Stabilizing amorphous form
• Improving handling of APIs
• Applicable for a broad range of API

NLAB Spiro™

• Spherical particles
• 2 to 5 µm
• Tuneable particle and pore size
• High loading up to 50%
• Free-flowing powder