Drug delivery is a broad concept in the pharmaceutical industry. It involves different ways to administer medicines, as well as various techniques to formulate and manufacture drugs. Nanologica operates within a niche domain of the former which is called “nanocarriers”.
With the aid of nano-based drug delivery technologies, there is the potential to solve many global challenges which today impede or prevent effective treatment of serious diseases. These include the stabilization and controlled release of large molecules, such as peptides and proteins, which are used in biological drugs and in targeting cancer drugs at tumor tissue. Another option is to boost the body’s absorption of drugs that are poorly soluble in water. Poor solubility of a drug substance in water generally results in poor efficacy of the drug because the body is a water-based system, and the substance has to be in dissolved form to reach the place in the body where it is effective.
NLAB Silica™ involves porous particles in a micrometer format. Nanologica’s drug delivery technology can be described simply as loading the pores in the particles with a drug substance, and then compressing the particles into tablets. When the patient takes the tablet, the drug is gradually released into the stomach and/or intestines. The drug is then absorbed by the body, while the particles pass through and are excreted. By storing, stabilizing and transporting the drug substance inside the particles’ pores, the efficacy of the drug is maintained.
The most common problem with poorly soluble drug substances is that the natural state is a crystalline form which cannot be absorbed by the body, while the amorphous form which has a medical effect is unstable. By loading the unstable, amorphous form of the drug substance in NLAB Silica™, the substance is stabilized, which increases the body’s ability to absorb the drug. In this way, treatments can be made more effective, doses reduced and in some cases completely new drugs created.
Most research during the past few decades has resulted in new biological drugs which use large molecules, such as peptides and proteins, to treat diseases which have been difficult to treat with traditional drugs. Many of these new drugs have stability problems and disintegrate when handled. This problem can be resolved by loading the drug molecules into NLAB Silica™. Nanologica has conducted animal studies with the release of peptides from NLAB Silica™. The results were very promising and the patent application has been submitted.
The pores in NLAB Silica™ particles (gray) are loaded with a drug substance (green), and the particles are then compressed into tablets. When the patient takes the tablet, the drug is gradually released into the stomach and/or intestines. The drug is then absorbed by the body, while the particles pass through and are excreted.